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The Wang Lab

Publications

Macromolecular Condensation

M.A. Kreutzberger, E. Tejada, Y. Wang, P.F. Almeida. GUVs melt like LUVs: the large heat capacity of MLVs is not due to large size or small curvature. Biophysical Journal. 12(2), 411-419 (2015).

PubMed

Team Authors:

Y. Wang, A. Lomakin, T. Hideshima, J.P. Laubach, O.O. Ogun, P.G. Richardson, N.C. Munshi, K.C. Anderson, G.B. Benedek. Pathological crystallization of human immunoglobulins. Proc. Natl. Acad.Sci. USA. 109, 13359-13361(2012).

PubMed

Team Authors:

Y. Wang, A. Lomakin, R.F. Latypov, G.B. Benedek. Phase separation in solutions of monoclonal antibodies and the effect of human serum albumin. Proc. Natl. Acad.Sci. USA. 108, 16606-16611 (2011).

PubMed

Team Authors:

Y. Wang, A. Lomakin, J.J. McManus, O. Ogun, G.B. Benedek. Phase behavior of mixtures of human lens proteins Gamma D and Beta B1. Proc. Natl. Acad.Sci. USA. 107, 13282-13287 (2010).

PubMed

Team Authors:

O. Annunziata, A. Payne and Y. Wang. Solubility of lysozyme in the presence of aqueous chloride salts: common-ion effect and its role on solubility and crystal thermodynamics. J. Am. Chem. Soc. 130, 13347-13352 (2008).

PubMed

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Y. Wang and O. Annunziata. Liquid-liquid phase transition of protein aqueous solutions isothermally induced by protein crosslinking. Langmuir. 24, 2799-2807 (2008).

PubMed

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Y. Wang and O. Annunziata. Comparison between protein-PEG interactions and the effect of PEG on protein-protein interactions using the liquid-liquid phase transition. J. Phys. Chem. B. 111, 1222-1230 (2007).

PubMed

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Biopharmaceutical Formulation

M. J. Scannell, M. W. Hyatt, I. L. Budyak, M. A. Woldeyes, Y. Wang. Revisit PEG-Induced Precipitation Assay for Protein Solubility Assessment of Monoclonal Antibody Formulations. Pharmaceutical Research. PMID: 34647231 (2021).

PubMed

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Y. Wang, R. F. Latypov. Quantitative Evaluation of Protein Solubility in Aqueous Solutions by PEG-Induced Liquid-Liquid Phase Separation. Methods in Molecular Biology. 2039, 39-49 (2019).

PubMed

Team Authors:

J.B. Rowe, R.P. Flynn, H.R. Wooten, H.A. Noufer, R.A. Cancel, J. Zhang, J.A. Subramony, S. Pechenov, Y. Wang. Submicron Aggregation of Chemically Denatured Monoclonal Antibody. Molecular Pharmaceutics. 15, 4710-4721 (2018).

PubMed

Team Authors:

J.B. Rowe, R.A. Cancel, T.D. Evangelous, R.P. Flynn, S. Pechenov, J.A. Subramony, J. Zhang, Y. Wang. Meta-stability Gap in the Phase Diagram of Monoclonal IgG Antibody. Biophysical Journal. 113, 1750-1756 (2017).

PubMed

Team Authors:

Y. Wang, A. Lomakin, S. Kanai, R. Alex, G.B. Benedek. Liquid-Liquid Phase Separation in Oligomeric Peptide Solutions. Langmuir. 33, 7715-7721 (2017).

PubMed

Team Authors:

G. Sun, Y. Wang, A. Lomakin, G. B. Benedek, H. E. Stanley, L. Xu, S. V. Buldyrev. The Phase Behavior Study of Human Antibody Solution Using Multi-scale Modeling. The Journal of Chemical Physics. 145, 194901 (2016).

PubMed

Team Authors:

R.W. Thompson, R.F. Latypov, Y. Wang, A. Lomakin, J.A. Meyer, S. Vunnum, G. B. Benedek. Evaluation of effects of pH and ionic strength on colloidal stability of IgG solutions by PEG-induced liquid-liquid phase separation. The Journal of Chemical Physics. 145, 185101 (2016).

PubMed

Team Authors:

Y. Wang, A. Lomakin, S. Kanai, R. Alex, S. Belli, M. Donzelli, G. B. Benedek. The molecular basis for the prolonged blood circulation of lipidated incretin peptides: peptide oligomerization or binding to serum albumin. Journal of Controlled Release. 241, 25-33 (2016).

PubMed

Team Authors:

Y. Wang, A. Lomakin, S. Kanai, R. Alex, G.B. Benedek. Transformation of oligomers of lipidated peptide Induced by Change in pH. Molecular Pharmaceutics. 12(2), 411-419 (2015).

PubMed

Team Authors:

Y. Wang, R.F. Latypov, A. Lomakin, J.A. Meyer, B.A. Kerwin, S. Vunnum, G.B. Benedek. Quantitative evaluation of colloidal stability of antibody solutions using PEG-induced liquid-liquid phase separation.. Molecular Pharmaceutics. 11(5), 1391-1402 (2014).

PubMed

Team Authors:

Y. Wang, A. Lomakin, R.F. Latypov, J.P. Laubach, T. Hideshima, P.G. Richardson, N.C. Munshi, K.C. Anderson, G.B. Benedek. Phase transitions in human IgG solutions. J. Chem. Phys. 139, 121904(1-9) (2013).

PubMed

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The Wang Lab

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The Wang Lab

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